Polymorphisms in BER and NER pathway genes: effects on micronucleus frequencies among vinyl chloride-exposed workers in Northern China.

@article{Wang2013PolymorphismsIB,
  title={Polymorphisms in BER and NER pathway genes: effects on micronucleus frequencies among vinyl chloride-exposed workers in Northern China.},
  author={Qi Wang and Hong-shan Tan and Fang Zhang and Yuan Sun and Nan-nan Feng and Li-fang Zhou and Yun-jie Ye and Yi-liang Zhu and Yong-liang Li and Paul Wesley Brandt-Rauf and Hua Shao and Zhao-lin Xia},
  journal={Mutation research},
  year={2013},
  volume={754 1-2},
  pages={7-14}
}
In this study, a group of 317 workers occupationally exposed to vinyl chloride monomer and 166 normal, unexposed referents in Shandong province (Northern China) were examined for chromosomal damage in peripheral lymphocytes using the cytokinesis-blocked micronucleus (CB-MN) assay. The exposure group (3.47±2.65)‰ showed higher micronucleus frequency than the unexposed workers (2.51±1.96)‰ (P<0.01). We explored the relationship between genetic polymorphisms of XRCC1 (-77C/T, Arg194Trp, Arg280His… CONTINUE READING