Polymorphisms at the glutathione S-transferase GSTM1, GSTT1 and GSTP1 loci: risk of ovarian cancer by histological subtype.

@article{Spurdle2001PolymorphismsAT,
  title={Polymorphisms at the glutathione S-transferase GSTM1, GSTT1 and GSTP1 loci: risk of ovarian cancer by histological subtype.},
  author={Amanda B Spurdle and Penelope M Webb and David M. Purdie and Xiao-qing Chen and A Richard Green and Georgia Chenevix-Trench},
  journal={Carcinogenesis},
  year={2001},
  volume={22 1},
  pages={
          67-72
        }
}
The phase II glutathione S-transferases (GSTs) GSTT1, GSTM1 and GSTP1 catalyse glutathione-mediated reduction of exogenous and endogenous electrophiles. These GSTs have broad and overlapping substrate specificities and it has been hypothesized that allelic variants associated with less effective detoxification of potential carcinogens may confer an increased susceptibility to cancer. To assess the role of GST gene variants in ovarian cancer development, we screened 285 epithelial ovarian cancer… CONTINUE READING

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