Polymorphisms associated with cholesterol and risk of cardiovascular events.

  title={Polymorphisms associated with cholesterol and risk of cardiovascular events.},
  author={Sekar Kathiresan and Olle Melander and Dragi Anevski and Candace Guiducci and No{\"e}l P. Burtt and Charlotta Roos and Joel Hirschhorn and G{\"o}ran GB Berglund and Bo Hedblad and Leif Groop and David M Altshuler and Christopher H. Newton-Cheh and Marju Orho-Melander},
  journal={The New England journal of medicine},
  volume={358 12},
BACKGROUND Common single-nucleotide polymorphisms (SNPs) that are associated with blood low-density lipoprotein (LDL) or high-density lipoprotein (HDL) cholesterol modestly affect lipid levels. We tested the hypothesis that a combination of such SNPs contributes to the risk of cardiovascular disease. METHODS We studied SNPs at nine loci in 5414 subjects… CONTINUE READING