Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives.

@article{Riddle2006PolymorphismsAH,
  title={Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives.},
  author={Evan L Riddle and Brinda K. Rana and Kenton K Murthy and Fangwen Rao and Eleazar Eskin and Daniel T. O'Connor and Paul A. Insel},
  journal={Hypertension},
  year={2006},
  volume={47 3},
  pages={415-20}
}
Regulator of G protein signaling (RGS) proteins stimulate the GTPase activity of Galpha subunits of heterotrimeric G proteins, thereby negatively regulating G protein-coupled receptor signaling. RGS2, which preferentially alters Galphaq-mediated signaling, may be important for cardiovascular health, because knockout of RGS2 in mice is associated with altered smooth muscle relaxation and hypertension. In this study, we determined genetic variation in the human RGS2 gene by sequencing DNA in… CONTINUE READING

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