Polymorphisms and haplotypes of the NBS1 gene in childhood acute leukaemia.

  title={Polymorphisms and haplotypes of the NBS1 gene in childhood acute leukaemia.},
  author={Maria Mosor and Iwona Zi{\'o}łkowska and Danuta Januszkiewicz-Lewandowska and Jerzy Stanisław Nowak},
  journal={European journal of cancer},
  volume={44 15},
DNA repair gene polymorphisms and mutations may influence cancer risk. The product of the NBS1 gene, nibrin, is functionally involved in the double-strand DNA break repair system. Heterozygous, germline mutations of the NBS1 gene are associated with an increased risk of tumours. Thus, common polymorphism and haplotypes of NBS1 may contribute to the risk of cancer. This study verified whether polymorphisms of the NBS1 gene may influence susceptibility to the development of childhood acute… CONTINUE READING

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