Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD.

  title={Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD.},
  author={Judith C W Mak and Siu Pang Ho and Wai Cho Yu and Kelvin L Choo and Chung Ming Chu and Wing Wai Yew and Wah Kit Lam and M Chan-yeung},
  journal={The European respiratory journal},
  volume={30 4},
Increased oxidative stress has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study investigated the risk of COPD and the substitution of alanine 16 with valine (Ala16Val) polymorphism of manganese-superoxide dismutase (Mn-SOD) and the cytosine to thymidine transition of nucleotide -262 (-262C>T) polymorphism of the catalase gene, and the activity of erythrocyte SOD and catalase. The subjects were stable COPD patient ever smokers (n = 165) and healthy… CONTINUE READING


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Polymorphisms of superoxide dismutase and catalase genes and functional activity levels in Chinese patients with asthma

JCW Mak, HCM Leung, SP Ho
Clin Exp Allergy • 2006

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