Polymorphisms and a Haplotype in Heparanase Gene Associations with the Progression and Prognosis of Gastric Cancer in a Northern Chinese Population

@inproceedings{Li2012PolymorphismsAA,
  title={Polymorphisms and a Haplotype in Heparanase Gene Associations with the Progression and Prognosis of Gastric Cancer in a Northern Chinese Population},
  author={Ai-Lin Li and Yongxi Song and Zhenning Wang and P. P. Gao and Y. Z. Miao and Jin-liang Zhu and Zhen-yu Yue and Huimian Xu},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Human heparanase plays an important role in cancer development and single nucleotide polymorphisms (SNPs) in the heparanase gene (HPSE) have been shown to be correlated with gastric cancer. The present study examined the associations between individual SNPs or haplotypes in HPSE and susceptibility, clinicopathological parameters and prognosis of gastric cancer in a large sample of the Han population in northern China. METHODOLOGY/PRINCIPAL FINDINGS Genomic DNA was extracted from… CONTINUE READING