Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics.

@article{Johnson2005PolymorphismsAG,
  title={Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics.},
  author={Andrew D. Johnson and Danxin Wang and Wolfgang Sadee},
  journal={Pharmacology & therapeutics},
  year={2005},
  volume={106 1},
  pages={19-38}
}
Functional polymorphisms that alter gene expression and mRNA processing appear to play a critical role in shaping human phenotypic variability. Intensive studies on polymorphisms affecting drug response have revealed multiple modes of altered gene function, frequently involving cis-acting regulatory sequence variants. Experimental and in silico methods have advanced the search for such polymorphisms, but considerable challenges remain. Here, a survey of polymorphisms in drug-related genes… CONTINUE READING

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