Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus

@inproceedings{Palles2015PolymorphismsNT,
  title={Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus},
  author={Claire Palles and Laura Chegwidden and Xinzhong Li and John M. Findlay and Garry G S Farnham and Francesc Castro Giner and Maikel P Peppelenbosch and Michal B. Kovac and Claire L. Adams and Hans Prenen and Sarah EW Briggs and Rebecca B. Harrison and Scott Sanders and David B S Macdonald and Chris R Haigh and Art T Tucker and Sharon B Love and Manoj Nanji and John Decaestecker and David Raymond Ferry and Barrie J Rathbone and Julie Hapeshi and Hugh Barr and Paul M Moayyedi and Peter A. Watson and Barbara Zietek and Neera Maroo and Laura Gay and Tim J. Underwood and Lisa Boulter and Hugh McMurtry and David W. Monk and Praful Patel and Krish Ragunath and David Al Dulaimi and Iain Alexander Murray and Konrad Koss and Andrew M. Veitch and Nigel John Trudgill and Chuka U. Nwokolo and Bjorn Joakim Rembacken and Paul A Atherfold and Elaine K Green and Yeng Ang and Ernst J Kuipers and Wu Chow and Stuart K. Paterson and Sudarshan Kadri and Ian Beales and Charles Grimley and Paul Mullins and Conrad Beckett and Mark Farrant and Andrew D Dixon and Sean Kelly and Matthew B Johnson and Shahjehan Wajed and Anjan Dhar and Elinor J. Sawyer and Rebecca R Roylance and Lynn E. Onstad and Marilie Denise Gammon and Douglas A. Corley and N J Shaheen and Nigel Charles Bird and Laura J. Hardie and Brian J. Reid and Weimin Ye and Geoffrey L. Liu and Yvonne Romero and Leslie Bernstein and Anna H Wu and Alan G. Casson and Rebecca C Fitzgerald and David C Whiteman and Harvey A. Risch and David M. Levine and Tom L. Vaughan and Auke P. Verhaar and Jan H. M. van den Brande and Eelke Lucie Anne Toxopeus and Manon V M C W Spaander and Bas P. L. Wijnhoven and Luc J W van der Laan and Kausilia K Krishnadath and Cisca Wijmenga and Gosia Trynka and Ross McManus and John Vincent Reynolds and Jacintha N. O’Sullivan and Padraic Macmathuna and Sarah A. McGarrigle and Dermot Kelleher and S{\'e}verine Vermeire and Isabelle Cleynen and Raf Bisschops and Ian P. M. Tomlinson and Janusz Jankowski},
  booktitle={Gastroenterology},
  year={2015}
}
BACKGROUND & AIMS Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subsequently, the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) identified risk loci for BE and esophageal adenocarcinoma near CRTC1 and BARX1, and within 100 kb of FOXP1. We aimed to… CONTINUE READING
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