Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients.

@article{Carregaro2010PolymorphismsIA,
  title={Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients.},
  author={Fernanda Carregaro and Adriana Carta and Jos{\'e} Antonio Cordeiro and Suzana Margareth Ajeje Lobo and Eloiza H Tajara da Silva and A M Leopoldino},
  journal={Memorias do Instituto Oswaldo Cruz},
  year={2010},
  volume={105 5},
  pages={649-56}
}
Genetic variation in immune response is probably involved in the progression of sepsis and mortality in septic patients. However, findings in the literature are sometimes conflicting or their significance is uncertain. Thus, we investigated the possible association between 12 polymorphisms located in the interleukin-6 (IL6), IL10, TLR-2, Toll-like receptor-4 (TLR-4), tumor necrosis factor-α and tumor necrosis factor-β (lymphotoxin α--LTA) genes and sepsis. Critically ill patients classified… CONTINUE READING
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