Polymorphisms A387P in thrombospondin‐4 and N700S in thrombospondin‐1 perturb calcium binding sites

  title={Polymorphisms A387P in thrombospondin‐4 and N700S in thrombospondin‐1 perturb calcium binding sites},
  author={O. Stenina and V. Ustinov and I. Krukovets and Tina E. Marinic and E. Topol and E. Plow},
  journal={The FASEB Journal},
  • O. Stenina, V. Ustinov, +3 authors E. Plow
  • Published 2005
  • Medicine, Biology
  • The FASEB Journal
  • Recent genetic studies have associated members of the thrombospondin (TSP) gene family with premature cardiovascular disease. The disease‐associated polymorphisms lead to single amino acid changes in TSP‐4 (A387P) and TSP‐1 (N700S). These substitutions reside in adjacent domains of these highly homologous proteins. Secondary structural predictive programs and the homology of the domains harboring these amino acid substitutions to those in other proteins pointed to potential alterations of… CONTINUE READING
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