Polymorphisms/mutations of TCR-zeta-chain promoter and 3' untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3' untranslated region in patients with systemic lupus erythematosus.

@article{Nambiar2001PolymorphismsmutationsOT,
  title={Polymorphisms/mutations of TCR-zeta-chain promoter and 3' untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3' untranslated region in patients with systemic lupus erythematosus.},
  author={Madhusoodana P. Nambiar and Edith J Enyedy and Vishal G. Warke and Sandeep H Krishnan and Glynn Dennis and Gary M. Kammer and George C Tsokos},
  journal={Journal of autoimmunity},
  year={2001},
  volume={16 2},
  pages={133-42}
}
A vast majority of systemic lupus erythematosus (SLE) patients display decreased expression of TCR zeta-chain mRNA, a critical signaling molecule implicated in the selection of the TCR repertoire and in the prevention of autoimmunity. To identify the molecular mechanisms involved in the downregulation of TCR zeta-chain transcripts in SLE T cells, we investigated the possibility of polymorphisms/mutations in the promoter and the 3' untranslated region. PCR, cloning and sequence analysis of the… CONTINUE READING