Polymorphism rs3123554 in CNR2 reveals gender-specific effects on body weight and affects loss of body weight and cerebral insulin action.

@article{Ketterer2014PolymorphismRI,
  title={Polymorphism rs3123554 in CNR2 reveals gender-specific effects on body weight and affects loss of body weight and cerebral insulin action.},
  author={Caroline Ketterer and Martin Heni and Krunoslav T. Stingl and Otto Tschritter and Katarzyna Linder and Robert Christian Wagner and Fausto Machicao and Hans-Ulrich H{\"a}ring and Hubert Preissl and Harald Staiger and Andreas Fritsche},
  journal={Obesity},
  year={2014},
  volume={22 3},
  pages={925-31}
}
OBJECTIVE The cannabinoid-receptor system is involved in the regulation of food intake. Here, we test whether single nucleotide polymorphisms (SNPs) in CNR2, encoding the cannabinoid-receptor 2, are associated with weight in a cross-sectional cohort. Furthermore, we wanted to investigate if the identified hits influence weight loss during lifestyle intervention; and study a potential involvement of cerebral insulin action. METHODS 2006 subjects at increased risk for type 2 diabetes mellitus… CONTINUE READING
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