Polymorphism of tubulin oligomers in the presence of microtubule-associated proteins. Implications in microtubule assembly.

@article{Carlier1984PolymorphismOT,
  title={Polymorphism of tubulin oligomers in the presence of microtubule-associated proteins. Implications in microtubule assembly.},
  author={M F Carlier and Christoph Simon and Dominique Pantaloni},
  journal={Biochemistry},
  year={1984},
  volume={23 7},
  pages={1582-90}
}
The interaction between tubulin and microtubule-associated proteins (MAPs) in solutions of cycled microtubule protein has been studied by using radioactively labeled MAPs. Kinetic data of MAP association to microtubules in the polymerization process indicate that an oligomer P of tubulin and MAPs is the polymerizing species. Analysis of MAP binding to microtubules formed from solutions in which the ratio MAPs/tubulin was varied shows evidence for a polymorphism of tubulin-MAP oligomers. When… CONTINUE READING