Polymorphism of transporter associated with antigen presentation 1 as a potential determinant for severity of disease in recurrent respiratory papillomatosis caused by human papillomavirus types 6 and 11.

@article{Vambutas2004PolymorphismOT,
  title={Polymorphism of transporter associated with antigen presentation 1 as a potential determinant for severity of disease in recurrent respiratory papillomatosis caused by human papillomavirus types 6 and 11.},
  author={Andrea Vambutas and Vincent R Bonagura and Elaine F. Reed and Allan L. Abramson and Virginia Mullooly and J Devoti and David Gjertson and Bettie M. Steinberg},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={189 5},
  pages={
          871-9
        }
}
Recurrent respiratory papillomatosis (RRP) is a rare disease caused by human papillomaviruses (HPVs). It is characterized by multiple recurrences of benign neoplasms and has a variable clinical course, ranging from infrequent recurrence to acute airway obstruction. One way in which HPV subverts the immune system in RRP is by interfering with TAP1 (transporter associated with antigen presentation 1). We examined whether a known TAP1 polymorphism in the ATPase domain altered the severity of… 
View on PubMed
academic.oup.com
22 Citations
Highly Influential Citations
1
Background Citations
5

22 Citations

Citation Type

Citation Type

Association between the TAP1 gene polymorphisms and recurrent respiratory papillomatosis in patients from Western Mexico: A pilot study
TLDR
The present study aimed to determine the association between the TAP1 rs1057141 and rs1135216 single nucleotide polymorphisms (SNPs) and RRP and found that individuals with those polymorphisms are susceptible to immune, infectious, and tumor‐related diseases.
Associations of HLA-DRB1 and -DQB1 alleles with severe recurrent respiratory papillomatosis in Korean patients.
HLA alleles, IFN-gamma responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis.
[Recurrent respiratory papillomatosis in a pediatric patient: case report].
TLDR
The case of a 5-year-old child in whom chronic laryngeal papillomatosis, probably acquired vertically during labor, was detected is reported, and further studies are needed to identify the most prevalent HLA alleles in the Latino population and their potential association with genetic susceptibility in Recurrent Respiratory Papillmatosis.
Identification of Key Amino Acid Residues That Determine the Ability of High Risk HPV16-E7 to Dysregulate Major Histocompatibility Complex Class I Expression*
TLDR
The experiments demonstrate that the C-terminal region within the zinc finger domain of HPV-E7 is responsible for the contrasting effects of HPV11- and HPV16- E7 on MHC I, and identify for the first time a residue variation at position 88 that is highly critical for HPV16/E7-mediated suppression of MHCI.
Immune Dysregulation and Tumor-Associated Gene Changes in Recurrent Respiratory Papillomatosis: A Paired Microarray Analysis
TLDR
It is proposed that HPV 6 and 11 infection establishes a tumorigenic microenvironment characterized by alteration of both innate inflammatory signals and adaptive immune responses that prevent effective TH1-like response, in conjunction with altered expression of numerous genes that regulate cellular growth and differentiation.
Immunological tolerance of low‐risk HPV in recurrent respiratory papillomatosis
TLDR
Molecular insights into RRP, in particular the interplay between RRP and the immune system, are needed to advance the understanding of this disease and may lead to the identification of immunomodulatory agents to better manage RRP.
in Respiratory Papillomatosis Human Papillomavirus Type 11 E 6 Protein Interleukin-10 Expression in Response to Failure of Gamma Interferon but Not
  • 2004
Failure of Gamma Interferon but Not Interleukin-10 Expression in Response to Human Papillomavirus Type 11 E6 Protein in Respiratory Papillomatosis
TLDR
E6 is the dominant inducer of cytokine expression in RRP, and it induces a skewed expression of IL-10 compared to the expression of IFN-γ, which is more prominent for TH1-like cytokine Expression by patients with severe disease.
Risk factors for the development and severity of juvenile-onset recurrent respiratory papillomatosis: a systematic review.
...
1
2
3
...

References

SHOWING 1-10 OF 65 REFERENCES
Altered Expression of TAP-1 and Major Histocompatibility Complex Class I in Laryngeal Papillomatosis: Correlation of TAP-1 with Disease
TLDR
It is suggested that HPV may evade immune recognition by down-regulating class I MHC cell surface expression via decreased TAP-1 levels, which provides some promise for nonsurgical treatment of laryngeal papillomas.
Association of polymorphisms in human leukocyte antigen class I and transporter associated with antigen processing genes with resistance to human immunodeficiency virus type 1 infection.
TLDR
It is suggested that differential preferences for amino acids at the C terminus may influence peptide-binding capacity, and TAP2 Ala665 was associated with resistance to HIV-1 infection, perhaps because of its higher efficiency in transporting peptides, thus eliciting a greater CD8(+) T cell response, or because of linkage disequilibrium.
Involvement of transporter associated with antigen processing 2 (TAP2) gene polymorphisms in hepatitis C virus infection.
A single nucleotide polymorphism of the low molecular mass polypeptide 7 gene influences the interferon response in patients with chronic hepatitis C
TLDR
It is suggested that a single nucleotide polymorphism of LMP7 gene is one of the important host factors which independently influence the response to interferon (IFN) treatment in patients with chronic hepatitis C.
Interaction of human papillomavirus type 11 E7 protein with TAP-1 results in the reduction of ATP-dependent peptide transport.
TLDR
The interaction of E7 with T AP-1 prevents TAP-1 antibody detection and efficient peptide transport, resulting in poor presentation of viral antigen on HPV-infected cells and thus failure to mount an effective immune-mediated prevention of disease recurrence.
HLA Class II Polymorphisms and Susceptibility to Recurrent Respiratory Papillomatosis
TLDR
Recurrent respiratory papillomatosis (RRP) is characterised by multiple laryngeal papillomas, and since oral HPV infection is common and RRP is rare, other host and/or viral factors may contribute to pathogenesis.
Polymorphisms of the human leukocyte antigen DRB1 and DQB1 genes and the natural history of human papillomavirus infection.
TLDR
The results suggest that HLA class II polymorphisms are involved in clearance and maintenance of HPV infection.
Transporter associated with antigen-processing (TAP) genes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis.
TLDR
This study along with earlier studies on HLA association in mycobacterial diseases suggests that in addition to HLA-DR15 alleles in the TAP2 region influence susceptibility to PTB and TT leprosy.
Human leukocyte antigen class II and cervical cancer risk: a population-based study.
TLDR
Results add to the evidence that certain HLA class II alleles or allele combinations, or genes linked to them, make some women more susceptible to SCC.
Polymorphisms of the TAP2 gene may influence antibody response to live measles vaccine virus.
...
1
2
3
4
5
...