Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy.

@article{Ikoma2003PolymorphismOT,
  title={Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy.},
  author={Eiko Ikoma and Takashi Tsunematsu and Ichirou Nakazawa and Tadashi Shiwa and Kiyoshi Hibi and Toshiaki Ebina and Yasuyuki Mochida and Yoshiyuki Toya and Hideaki Hori and Kazuaki Uchino and Susumu Minamisawa and Kazuo Kimura and Satoshi Umemura and Yoshihiro Ishikawa},
  journal={Journal of cardiovascular pharmacology},
  year={2003},
  volume={42 Suppl 1},
  pages={S27-32}
}
We investigated whether polymorphism of the type 6 adenylyl cyclase gene influences the occurrence of left ventricular hypertrophy in a Japanese population. Type 6 adenylyl cyclase is a major cardiac adenylyl cyclase isoform and plays an important role in regulating cardiac function. We examined the type 6 adenylyl cyclase gene for single nucleotide polymorphism by heteroduplex analysis and found a mutation (T11215A) in intron 17. We genotyped the single nucleotide polymorphism (TT/TA/AA groups… CONTINUE READING