Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study.

@article{Fornage2004PolymorphismOT,
  title={Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study.},
  author={Myriam Fornage and Eric Boerwinkle and P. A. Doris and David Jacobs and Kiang Liu and Nathan D Wong},
  journal={Circulation},
  year={2004},
  volume={109 3},
  pages={335-9}
}
BACKGROUND Modulation of endogenous epoxide levels by soluble epoxide hydrolase (sEH) in the endothelium represents an important mechanism in the regulation of cardiovascular function. We examined the relationship between a common, functional polymorphism of the human sEH gene and coronary artery calcification (CAC) in young, largely asymptomatic African-American and non-Hispanic white subjects. METHODS AND RESULTS Multiple logistic regression and Tobit regression models were used to assess… CONTINUE READING

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