Polymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene and clozapine-induced weight gain.

@article{Reynolds2003PolymorphismOT,
  title={Polymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene and clozapine-induced weight gain.},
  author={Gavin Paul Reynolds and Zhi-Jun Zhang and Xiaobin Zhang},
  journal={The American journal of psychiatry},
  year={2003},
  volume={160 4},
  pages={677-9}
}
OBJECTIVE Weight gain, leading to further morbidity and poor treatment adherence, is a common consequence of treatment with antipsychotic drugs. A recent study showed that a polymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene is associated with antipsychotic-induced weight gain. The authors determined whether this association held true for weight gain after clozapine treatment. METHOD Thirty-two Chinese Han patients with first-episode schizophrenia were genotyped for… CONTINUE READING

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