Polymorphism of the promoter region of C-509T of transforming growth factor-beta1 gene and ulcerative colitis.


BACKGROUND Transforming growth factor-beta is a regulatory protein that plays a key role in inflammatory, fibrotic, and immunological events in the intestinal mucosa. Recently, attention has been focused on the role of transforming growth factor-beta in the etiopathogenesis of inflammatory bowel disease. Enhanced expression of transforming growth factor… (More)

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