Polymorphism of the prion protein is associated with cognitive impairment in the elderly

  title={Polymorphism of the prion protein is associated with cognitive impairment in the elderly},
  author={C. Berr and F. Richard and C. Dufouil and C. Amant and A. Alp{\'e}rovitch and P. Amouyel},
  pages={734 - 737}
  • C. Berr, F. Richard, +3 authors P. Amouyel
  • Published 1998
  • Biology, Medicine
  • Neurology
  • Background: Little is known about the role of the prion protein (PrPsen/gene PRNP). PRNP knockout mice studies suggest that PrPsen may be involved in CNS degeneration. This observation prompted us to examine the influence of PRNP genetic variability on cognitive abilities in the elderly. Methods: In a community-based sample of 1,163 subjects aged 59 to 71 years, we characterized the valine (Val) and methionine (Met) allele of the PRNP polymorphism at codon 129. The effect of this polymorphism… CONTINUE READING
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