Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.

@article{Marez1997PolymorphismOT,
  title={Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.},
  author={D. Marez and M{\'e}lanie Legrand and N. Sabbagh and J M Lo Guidice and Catherine Spire and J. J. Lafitte and Urs A. Meyer and Franck Broly},
  journal={Pharmacogenetics},
  year={1997},
  volume={7 3},
  pages={193-202}
}
The polymorphic cytochrome P450 CYP2D6 is involved in the metabolism of various drugs of wide therapeutic use and is a presumed susceptibility factor for certain environmentally-induced diseases. Our aim was to define the mutations and alleles of the CYP2D6 gene and to evaluate their frequencies in the European population. Using polymerase chain reaction-single strand conformation polymorphism analysis, 672 unrelated subjects were screened for mutations in the 9 exons of the gene and their exon… CONTINUE READING
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