Polymorphism of the beta-2 adrenoceptor and IOP lowering potency of topical timolol in healthy subjects.


PURPOSE Beta-2 adrenoceptor antagonists such as timolol have been used in the treatment of glaucoma for more than 30 years. Several functionally important polymorphisms for the beta-2 receptor have been described. In the present study we hypothesized that a relation between the intraocular pressure (IOP) lowering effect of timolol and beta-2 adrenoceptor… (More)


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