Polymorphism of the 4-hydroxylation of debrisoquine in the San Bushmen of southern Africa.

@article{Sommers1988PolymorphismOT,
  title={Polymorphism of the 4-hydroxylation of debrisoquine in the San Bushmen of southern Africa.},
  author={De K. Sommers and John Moncrieff and J. C. Avenant},
  journal={Human toxicology},
  year={1988},
  volume={7 3},
  pages={273-6}
}
1. The metabolic oxidation of debrisoquine has been studied in a group of 96 San Bushmen. 2. The amounts of debrisoquine and 4-hydroxy-debrisoquine excreted in 0-8 h urine were measured and the metabolic ratio (% dose as debrisoquine/% dose as 4-hydroxy-debrisoquine) calculated. 3. On the basis of Caucasian criteria, that metabolic ratios greater than 12.6 represent poor metabolizers, 19% of the Bushmen were poor metabolizers in contrast to the 8-10% found in Caucasian studies. 4. Probit plots… CONTINUE READING