Polymorphism of interferon-gamma gene at position +874 and clinical characteristics of chronic hepatitis C.

@article{Dai2006PolymorphismOI,
  title={Polymorphism of interferon-gamma gene at position +874 and clinical characteristics of chronic hepatitis C.},
  author={C. Y. Dai and W P Chuang and M. -J. Hsieh and Li-Po Lee and N T Hou and Shinn-Cherng Chen and Z. Y. Lin and M H Hsieh and L Y Wang and Jun-Fa Tsai and Wen-Yu Chang and Ming-Lung Yu},
  journal={Translational research : the journal of laboratory and clinical medicine},
  year={2006},
  volume={148 3},
  pages={128-33}
}
A T-to-A polymorphic sequence at position +874 in the interferon (IFN)-gamma gene (+874 IFN-gamma) might be associated with disease susceptibilities. To investigate the influence of +874 IFN-gamma polymorphism on the hepatitis C virus (HCV) viral load and the severity of liver disease, the single nucleotide polymorphism (SNP) was determined in 302 histologically proved chronic hepatitis C (CHC) patients [M/F: 180/122, mean age: 48.8 +/- 11.6 years, HCV genotype 1b: 147 (48.7%), liver cirrhosis… CONTINUE READING

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