Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two DR β loci

@article{Wu1986PolymorphismOH,
  title={Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two DR $\beta$ loci},
  author={Shaokee Wu and T. Saunders and F. Bach},
  journal={Nature},
  year={1986},
  volume={324},
  pages={676-679}
}
Class II molecules encoded by the human major histocompatibility complex (MHC) are involved in regulating T-cell response to antigens1–3. The mechanisms for generating polymorphism in products of the MHC have been studied extensively for both the murine H–2 and the human HLA complex. Such studies indicate that point mutations plus selection have a major role in the generation of polymorphisms of class I and class II MHC genes4–8. However, a non-reciprocal gene conversion mechanism has been… Expand
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