Polymorphism of glutathione S-transferase loci GSTM1 and GSTT1 and susceptibility to colorectal cancer in Egypt.

@article{AbdelRahman1999PolymorphismOG,
  title={Polymorphism of glutathione S-transferase loci GSTM1 and GSTT1 and susceptibility to colorectal cancer in Egypt.},
  author={S. Z. Abdel-Rahman and Amr S Soliman and Melissa L Bondy and X ianchao Wu and Samy El-Badawy and Khaled G Mahgoub and S M Ismail and Ibrahim A. Seifeldin and Bernard Levin},
  journal={Cancer letters},
  year={1999},
  volume={142 1},
  pages={97-104}
}
Egypt has an unusually high proportion of early-onset colorectal cancer under age 40 years. Environmental exposures and low DNA repair capacity are among the risk factors. Because GSTM1 and GSTT1 gene deficiencies may act as risk modifiers for colorectal cancer risk, we investigated the relationship between genetic polymorphism in these genes and colorectal cancer risk in Egyptians. Sixty-six patients and 55 controls were included. Genotyping for GSTM1 and GSTT1 was conducted using PCR… CONTINUE READING

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