Polymorphism of beta2-glycoprotein I at codons 306 and 316 in patients with systemic lupus erythematosus and antiphospholipid syndrome.

@article{Gushiken1999PolymorphismOB,
  title={Polymorphism of beta2-glycoprotein I at codons 306 and 316 in patients with systemic lupus erythematosus and antiphospholipid syndrome.},
  author={Francisca Cecilia Gushiken and F. C. Arnett and Chul Kyun Ahn and Palaniappan Thiagarajan},
  journal={Arthritis and rheumatism},
  year={1999},
  volume={42 6},
  pages={
          1189-93
        }
}
OBJECTIVE To determine the frequency of mutations in the phospholipid binding domain of beta2-glycoprotein I (beta2GPI) in patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS), and to analyze the clinical correlations of such mutations with thromboembolic complications. METHODS Exons 7 and 8 of beta2GPI, which encode for its fifth domain, were amplified by polymerase chain reaction, and the presence of mutations was determined by restriction digestion and… CONTINUE READING

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