Polymorphism of aldehyde dehydrogenase and its application to alcoholism.


Aldehyde dehydrogenase (ALDH) consists of four different isozymes (I, II, III, IV). Among these, ALDH I shows genetic polymorphism (normal and deficient) in a population of Mongoloid origin. The significantly lower frequency of ALDH I deficiency was found in alcoholic patients compared with healthy controls. ALDH I deficiency is one of the important genetic factors in regulating alcohol consumption and plays a protective role against alcoholism. Population genetic studies on ALDH I deficiency in different ethnic groups indicate that ALDH deficiency was found only in Mongoloid population groups.


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@article{Harada1989PolymorphismOA, title={Polymorphism of aldehyde dehydrogenase and its application to alcoholism.}, author={Shoji Harada}, journal={Electrophoresis}, year={1989}, volume={10 8-9}, pages={652-5} }