Polymorphism of alcohol-metabolizing genes affects drinking behavior and alcoholic liver disease in Japanese men.

@article{Tanaka1997PolymorphismOA,
  title={Polymorphism of alcohol-metabolizing genes affects drinking behavior and alcoholic liver disease in Japanese men.},
  author={Fumiaki Tanaka and Yasushi Shiratori and Osamu Yokosuka and Fumio Imazeki and Yutaka Tsukada and Masao Omata},
  journal={Alcoholism, clinical and experimental research},
  year={1997},
  volume={21 4},
  pages={596-601}
}
Alcohol is known to be mainly metabolized in the liver by alcohol dehydrogenase 2 (ADH2) and aldehyde dehydrogenase 2 (ALDH2), and cytochrome P-450IIEI. The purpose of this study was to clarify the role of polymorphism of these ethanol-metabolizing enzymes in drinking behavior and the progression of alcoholic liver disease among Japanese men. Polymorphism of the ADH2, ALDH2, and P-45IIEI genes were determined by polymerase chain reaction, followed by restriction fragment-length polymorphism… CONTINUE READING

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