Polymorphism of LRP5, but not of TNFRSF11B, is associated with a decrease in bone mineral density in postmenopausal Maya-Mestizo women.

@article{CantoCetina2013PolymorphismOL,
  title={Polymorphism of LRP5, but not of TNFRSF11B, is associated with a decrease in bone mineral density in postmenopausal Maya-Mestizo women.},
  author={Thelma Canto-Cetina and Lucila Polanco Reyes and Lizbeth J Gonz{\'a}lez Herrera and David Rojano-Mej{\'i}a and Ram{\'o}n Mauricio Coral-V{\'a}zquez and Agust{\'i}n Coronel and Patricia Canto},
  journal={American journal of human biology : the official journal of the Human Biology Council},
  year={2013},
  volume={25 6},
  pages={713-8}
}
OBJECTIVE Osteoporosis is a complex disease characterized principally by low bone mineral density (BMD), which is determined by an interaction of genetic, metabolic, and environmental factors. The aim of this study was to analyze the possible association among one polymorphism of LRP5 and three polymorphisms of TNFRSF11B as well as their haplotypes with BMD variations in Maya-Mestizo postmenopausal women. METHODS We studied 583 postmenopausal women of Maya-Mestizo ethnic origin. A structured… CONTINUE READING