Polymorphism of INS VNTR is associated with glutamic acid decarboxylase antibodies and postprandial C-peptide in patients with onset of diabetes after 35 years of age.

@article{MatejkovBehanov2004PolymorphismOI,
  title={Polymorphism of INS VNTR is associated with glutamic acid decarboxylase antibodies and postprandial C-peptide in patients with onset of diabetes after 35 years of age.},
  author={M Matejkov{\'a}-Behanov{\'a} and Marketa Vankova and Martin Hill and Petr Kucera and Ondřej Cinek and M. V. Van Andel and Bela Bendlova},
  journal={Physiological research},
  year={2004},
  volume={53 2},
  pages={187-90}
}
Variability in the number of tandem repeats of the insulin gene (INS VNTR) is probably involved in the genetic regulation of insulin secretion. The aim of this study was to investigate the association of INS VNTR polymorphism with the presence of glutamic acid decarboxylase antibodies (GADA) and C-peptide levels in patients with the onset of diabetes after 35 years of age. We investigated 117 patients, median of age 63 (range 40-83) years, median of diabetes duration 8 (range 1-30) years; 31… CONTINUE READING

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