Polymorphism of HLA-B27: 105 subtypes currently known.

@article{Khan2013PolymorphismOH,
  title={Polymorphism of HLA-B27: 105 subtypes currently known.},
  author={Muhammad Asim Khan},
  journal={Current rheumatology reports},
  year={2013},
  volume={15 10},
  pages={362}
}
HLA-B27 has a high degree of genetic polymorphism, with 105 known subtypes, named HLA-B*27:01 to HLA-B*27:106, encoded by 132 alleles. The most common subtypes associated with ankylosing spondylitis are HLA-B*27:05 (Caucasians), HLA-B*27:04 (Chinese), and HLA-B*27:02 (Mediterranean populations). For Chinese populations, HLA-B*27:04 is associated with a greater ankylosing spondylitis risk than HLA-B*27:05. Two subtypes, HLA-B27*06 and HLA-B27*09, seem to have no disease association. These… CONTINUE READING