Polymorphism of FCGR3A gene in sarcoidosis.

  title={Polymorphism of FCGR3A gene in sarcoidosis.},
  author={Marlena J Typiak and Krzysztof Rębała and Maria Dudziak and Andrzej Dubaniewicz},
  journal={Human immunology},
  volume={75 4},
We showed increased level of immune complexes (ICs) with mycobacterial heat shock proteins (Mtb-hsp) and increased expression of receptors for Fc fragment of immunoglobulin G (FcγR) I-III on blood monocytes with their increased phagocytic activity, responsible for clearance of these ICs in sarcoidosis (SA). Since FcγRIIIa is the most crucial in this process, we genotyped 77 SA patients and 143 healthy controls with polymerase chain reaction for V158F polymorphism of FCGR3A gene, encoding Fc… CONTINUE READING
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