Polymorphism of DNA ligase I and risk of lung cancer--a case-control analysis.

  title={Polymorphism of DNA ligase I and risk of lung cancer--a case-control analysis.},
  author={Hongbing Shen and Margaret R. Spitz and Yawei Qiao and Yuxin Zheng and Waun Ki Hong and Qingyi Wei},
  journal={Lung cancer},
  volume={36 3},
DNA ligases catalyze the joining of single and double-strand DNA breaks, which is an essential step in DNA replication, recombination and repair. Recently, a common single nucleotide polymorphism (A-->C) in exon 6 of DNA ligase I (LIG1) was identified, but its functional relevance remains to be determined. Because LIG1 participates in DNA repair and reduced DNA repair capacity is associated with risk of lung cancer, we evaluated in a non-population-based case-control study of 530 lung cancer… CONTINUE READING


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