Polymorphism of Cystic Fibrosis Gene in Japanese Patients with Chronic Pancreatitis

@article{Kimura2000PolymorphismOC,
  title={Polymorphism of Cystic Fibrosis Gene in Japanese Patients with Chronic Pancreatitis},
  author={Sachiko Kimura and Yoshinori Okabayashi and Koichi Inushima and Yoshihiro Yutsudo and Masato Kasuga},
  journal={Digestive Diseases and Sciences},
  year={2000},
  volume={45},
  pages={2007-2012}
}
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and the 5T genotype of the polythymidine tract at the exon 9 splice branch/acceptor site are shown to be associated with chronic pancreatitis in Caucasian patients. In contrast to Western countries, cystic fibrosis is extremely rare in Japan. In this study, we investigated the association of mutations or polymorphisms of the CFTR gene with chronic pancreatitis in Japanese patients. Forty-seven patients with chronic… CONTINUE READING