Polymorphism of CD14 gene but not the mutation of TLR4 gene is associated with colorectal cancer in Chinese patients.

@article{Guo2006PolymorphismOC,
  title={Polymorphism of CD14 gene but not the mutation of TLR4 gene is associated with colorectal cancer in Chinese patients.},
  author={Qiusha Guo and Jianbo Zhu and Bing Xia},
  journal={Journal of gastroenterology and hepatology},
  year={2006},
  volume={21 1 Pt 1},
  pages={92-7}
}
OBJECTIVES Toll-like receptor 4 and CD14 are components of the lipopolysaccharide receptor complex. Our study aimed to investigate an association between TLR4 Asp299Gly and CD14-260 polymorphisms in Chinese patients with colorectal cancer. METHOD By a method of polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP), we genotyped TLR4 Asp299Gly and CD14-260 polymorphisms in 110 unrelated patients with colorectal cancer and 160 healthy controls from the Chinese Han… CONTINUE READING