Polymorphism in the human complement C4 genes and genetic susceptibility to autoimmune hepatitis.

@article{Doherty1994PolymorphismIT,
  title={Polymorphism in the human complement C4 genes and genetic susceptibility to autoimmune hepatitis.},
  author={Derek G. Doherty and James A Underhill and Peter T. Donaldson and Koji Manabe and Giorgina Mieli-Vergani and Adrian L. W. F. Eddleston and Diego Vergani and A. G. Demaine and Roger Williams},
  journal={Autoimmunity},
  year={1994},
  volume={18 4},
  pages={243-9}
}
Susceptibility to autoimmune hepatitis is associated with the HLA-DR3 and DR4 haplotypes, but which genes are directly involved in the pathogenesis, has not been established. Low levels of complement component C4 and elevated frequencies of C4 null allotypes have been described in patients, suggesting that the C4 genes, which are closely linked with the HLA loci, may play a role. We therefore examined restriction fragment length polymorphisms in the C4 and 21-hydroxylase genes, and determined… CONTINUE READING
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