Polymorphism in the Plasmodium falciparum erythrocyte-binding ligand JESEBL/EBA-181 alters its receptor specificity.

@article{Mayer2004PolymorphismIT,
  title={Polymorphism in the Plasmodium falciparum erythrocyte-binding ligand JESEBL/EBA-181 alters its receptor specificity.},
  author={D C Ghislaine Mayer and Jian-Bing Mu and Osamu Kaneko and Junhui Duan and Xin-zhuan Su and Louis H. Miller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 8},
  pages={2518-23}
}
The malaria parasite lives within erythrocytes and depends on the binding of parasite ligands to host cell surface receptors for invasion. The most virulent human malaria parasite, Plasmodium falciparum, uses multiple ligands, including EBA-175, BAEBL, and JESEBL of the Duffy-binding-like (DBL) family of erythrocyte-binding proteins, for invasion of human erythrocytes. Region II of these parasite ligands is the erythrocyte-binding domain. Previously, we had shown that polymorphism in region II… CONTINUE READING