Polymorphism in the Mr 32,000 Rh protein purified from Rh(D)-positive and -negative erythrocytes.

@article{Saboori1988PolymorphismIT,
  title={Polymorphism in the Mr 32,000 Rh protein purified from Rh(D)-positive and -negative erythrocytes.},
  author={A. M. Saboori and B. Smith and P. Agre},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 11},
  pages={
          4042-5
        }
}
  • A. M. Saboori, B. Smith, P. Agre
  • Published 1988
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • A Mr 32,000 integral membrane protein has previously been identified on erythrocytes bearing the Rh(D) antigen and is thought to contain the antigenic variations responsible for the different Rh phenotypes. To study it on a biochemical level, a simple large-scale method was developed to purify the Mr 32,000 Rh protein from multiple units of Rh(D)-positive and -negative blood. Erythrocyte membrane vesicles were solubilized in NaDodSO4, and a tracer of immunoprecipitated 125I surface-labeled Rh… CONTINUE READING
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    References

    SHOWING 1-2 OF 2 REFERENCES
    Basic and Clinical Immunohematology (Blackwell, Boston)
    • 1987
    Acquired immune hemolytic anemias
    • 174