Polymorphism in the IGF-I gene: clinical relevance for short children born small for gestational age (SGA).

@article{Arends2002PolymorphismIT,
  title={Polymorphism in the IGF-I gene: clinical relevance for short children born small for gestational age (SGA).},
  author={Nicolette J. T. Arends and Linda Johnston and Anita C. S. Hokken-Koelega and Cornelia van Duijn and Maria A. J. de Ridder and Martin O. Savage and Adrian J. L. Clark},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 6},
  pages={2720}
}
Low birth weight is associated with an increased risk in adult life of type 2 diabetes, hypertension and cardiovascular disease (CVD). The fetal insulin hypothesis postulates that genes involving insulin resistance could effect birth weight and disease in later life (Hattersley, 1999). Besides insulin, there is extensive evidence that insulin-like growth… CONTINUE READING