Polymorphism in paracetamol: evidence of additional forms IV and V at high pressure.

  title={Polymorphism in paracetamol: evidence of additional forms IV and V at high pressure.},
  author={Spencer J Smith and Matthew Bishop and Jeffrey M. Montgomery and Tracy P. Hamilton and Yogesh K. Vohra},
  journal={The journal of physical chemistry. A},
  volume={118 31},
The structural phase stability of N-(4-hydroxyphenyl) acetamide (paracetamol) has been studied at ambient temperature up to 23 GPa using Raman spectroscopy. Spectral changes have provided further evidence for a highly kinetically driven Form I → II transition that occurs as a mixed phase from 4.8 to 6.5 GPa, and might complete as early as 7 GPa. Upon further compression to 8.1 GPa, a drastic shift in spectral signature was observed providing the first evidence for a previously undiscovered Form… CONTINUE READING
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