Polymorphism in metoclopramide hydrochloride and metoclopramide.

  title={Polymorphism in metoclopramide hydrochloride and metoclopramide.},
  author={A G Mitchell},
  journal={The Journal of pharmacy and pharmacology},
  volume={37 9},
  • A G Mitchell
  • Published 1985 in The Journal of pharmacy and pharmacology
Metoclopramide hydrochloride (MCPHCl.H2O) and metoclopramide base (MCP) have been studied by DSC, thermomicroscopy, X-ray diffraction and infrared spectroscopy. MCPHCl.H2O does not readily lose water of crystallization either from the solid state or from the melt, but depending on the conditions, dehydration can give rise to two anhydrous polymorphs, MCPHCl/Form I (mp 187 degrees C) and MCPHCL/Form II (mp 155 degrees C). Form I crystallizes from the melt of Form II and not by a reversible solid… CONTINUE READING