Polymorphism in intron 2 of the interleukin-1 receptor antagonist gene, local midtrimester cytokine response to vaginal flora, and subsequent preterm birth.

@article{Gen2004PolymorphismII,
  title={Polymorphism in intron 2 of the interleukin-1 receptor antagonist gene, local midtrimester cytokine response to vaginal flora, and subsequent preterm birth.},
  author={Mehmet R Genç and Andrew B. Onderdonk and Santosh Vardhana and Mary L. Delaney and Errol R. Norwitz and Ruth E Tuomala and Lilly-Rose Paraskevas and Steven S Witkin},
  journal={American journal of obstetrics and gynecology},
  year={2004},
  volume={191 4},
  pages={1324-30}
}
OBJECTIVE This study investigated the association between polymorphism in intron 2 of the interleukin-1 receptor antagonist gene, midtrimester vaginal microflora, vaginal interleukin receptor antagonist and interleukin-1beta levels and subsequent spontaneous preterm birth. STUDY DESIGN Vaginal samples from 212 women, collected at 18-22 weeks' gestation, were analyzed for the polymorphism in intron 2 of the interleukin-1 receptor antagonist gene by polymerase chain reaction, qualitative and… CONTINUE READING
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