Polymorphism in endothelial connexin40 enhances sensitivity to intraluminal pressure and increases arterial stiffness.

@article{Chaston2013PolymorphismIE,
  title={Polymorphism in endothelial connexin40 enhances sensitivity to intraluminal pressure and increases arterial stiffness.},
  author={Daniel J. Chaston and Brett K. Baillie and T. Hilton Grayson and Raphael J Courjaret and Jillian M Heisler and Katherine A. Lau and Khaled Machaca and Bruce J Nicholson and Anthony W Ashton and Klaus Ingo Matthaei and Caryl E. Hill},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2013},
  volume={33 5},
  pages={962-70}
}
OBJECTIVE To determine whether impairment of endothelial connexin40 (Cx40), an effect that can occur in hypertension and aging, contributes to the arterial dysfunction and stiffening in these conditions. APPROACH AND RESULTS A new transgenic mouse strain, expressing a mutant Cx40, (Cx40T202S), specifically in the vascular endothelium, has been developed and characterized. This mutation produces nonfunctional hemichannels, whereas gap junctions containing the mutant are electrically, but not… CONTINUE READING
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