Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression.

  title={Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression.},
  author={Hanshao Liu and David K Chao and Emi E. Nakayama and Hayao Taguchi and Masatoshi Goto and Xiaoban Xin and Junki Takamatsu and Hiroshi Saito and Yoshihiro Ishikawa and Tatsuya Akaza and Takeo Juji and Y. Takebe and Takahiro Ohishi and Katsuyuki Fukutake and Yasushi Maruyama and Shinji Yashiki and Shunro Sonoda and Takuro Nakamura and Yoshiyuki Nagai and Aikichi Iwamoto and Tatsuo Shioda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 8},
RANTES (regulated on activation normal T cell expressed and secreted) is one of the natural ligands for the chemokine receptor CCR5 and potently suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Previous studies showed that peripheral blood mononuclear cells or CD4(+) lymphocytes obtained from different individuals had wide variations in their ability to secrete RANTES. These findings prompted us to analyze the upstream noncoding region of the RANTES… CONTINUE READING
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