Polymorphism in ARE-I region of prostate-specific antigen gene associated with low serum testosterone level and high-grade prostate cancer.

@article{Schatzl2005PolymorphismIA,
  title={Polymorphism in ARE-I region of prostate-specific antigen gene associated with low serum testosterone level and high-grade prostate cancer.},
  author={Georg Schatzl and Michael J Marberger and Mesut Remzi and Petra Gr{\"o}sser and Julia Unterlechner and Gerald Haidinger and Thomas Zidek and Martin Preyer and Michael Micksche and Andrea Gsur},
  journal={Urology},
  year={2005},
  volume={65 6},
  pages={1141-5}
}
OBJECTIVES To examine the impact of polymorphism in the androgen-responsive element I region of the prostate-specific antigen (PSA) gene on the serum testosterone level and Gleason score in patients with newly diagnosed, untreated prostate cancer (PCa). High-grade PCa is associated with a low serum testosterone level, and the testosterone level has been negatively correlated with the expression of PSA. METHODS Endocrine factors (including testosterone, follicle-stimulating hormone, and… CONTINUE READING

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