Polymorphism identification and cardiac gene expression analysis of the calsequestrin 2 gene in broiler chickens with sudden death syndrome.

@article{Basaki2016PolymorphismIA,
  title={Polymorphism identification and cardiac gene expression analysis of the calsequestrin 2 gene in broiler chickens with sudden death syndrome.},
  author={Mehdi Basaki and Keramat Asasi and Mohammad Reza Tabandeh and Mahmoud Aminlari},
  journal={British poultry science},
  year={2016},
  volume={57 2},
  pages={
          151-60
        }
}
Sudden death syndrome (SDS) in broilers is a cardiac disease associated with ventricular tachycardia (VT) and ventricular fibrillation (VF); however, its pathogenesis at the molecular level is not precisely determined. Downregulation and mutations of calsequestrin 2 (CASQ2), a major intracellular Ca(2+) buffer, have been associated with VT and sudden cardiac death (SCD) in humans but in chickens there is no report describing CASQ2 abnormalities in cardiac diseases. In order to better understand… CONTINUE READING
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