Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus

  title={Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus},
  author={Deborah S. Cunninghame Graham and Robert R. Graham and H. K. Manku and Andrew Kui-man Wong and John C. Whittaker and Patrick M Gaffney and Kathy L. Moser and John D Rioux and David Altshuler and Timothy W. Behrens and Timothy J Vyse},
  journal={Nature Genetics},
Systemic lupus erythematosus (SLE) is a multisystem complex autoimmune disease of uncertain etiology (OMIM 152700). Over recent years a genetic component to SLE susceptibility has been established. Recent successes with association studies in SLE have identified genes including IRF5 (refs. 4,5) and FCGR3B. Two tumor necrosis factor (TNF) superfamily members located within intervals showing genetic linkage with SLE are TNFSF4 (also known as OX40L; 1q25), which is expressed on activated antigen… CONTINUE READING
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