Polymorphism at the 5' end flanking region of the insulin gene is associated with reduced insulin secretion in healthy individuals.

@article{Cocozza1988PolymorphismAT,
  title={Polymorphism at the 5' end flanking region of the insulin gene is associated with reduced insulin secretion in healthy individuals.},
  author={Sergio Cocozza and Gabriele Riccardi and Antonella Monticelli and Brunella Capaldo and Salvatore Genovese and Vittorio Krogh and Egidio Celentano and Eduardo Farinaro and Stelio Varrone and Vittorio Enrico Avvedimento},
  journal={European journal of clinical investigation},
  year={1988},
  volume={18 6},
  pages={582-6}
}
Sixty-four unrelated healthy subjects were studied for the detection of a DNA polymorphism at the 5' end of the insulin gene. No significant difference between the groups was found in blood glucose values at fasting and after an oral glucose load. A significant association was found between fasting (P less than 0.05) and after load plasma C-peptide levels (P less than 0.01) and the presence of a 1.6 Kb insertion at the 5' end of the insulin gene. A gene dose-dependent effect was noted, class 3… CONTINUE READING

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