Polymorphism at codon 72 of p53, human papillomavirus, and cervical cancer in South India

@article{Pillai2002PolymorphismAC,
  title={Polymorphism at codon 72 of p53, human papillomavirus, and cervical cancer in South India},
  author={Radhakrishna M. Pillai and Srinivasan Sreevidya and Brad H Pollock and Puthuveetil Govindan Jayaprakash and Brian K Herman},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2002},
  volume={128},
  pages={627-631}
}
Abstract Purpose. It has been suggested that host genetic factors play a role in human papillomavirus (HPV)-associated tumorigenesis, although the issue continues to be a focus of much debate. Previous studies have reported that a common polymorphism of the wild type p53 gene at codon 72 of exon 4 (Arg/Arg) is associated with a sevenfold increased risk of HPV-associated cancer compared to Arg/Pro and Pro/Pro polymorphisms. In vitro studies also suggested that the Arg/Arg polymorphism was much… CONTINUE READING
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